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KMID : 0857020020170010147
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Kosin Medical Journal
2002 Volume.17 No. 1 p.147 ~ p.151
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Peripheral Polyneuropathy by Mixed Organic Solvents with Adrenal Insufficiency in Glue-Working A Case Report
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Kim Ghi-Chan
Kim Jin-Ha
Jeong Ho-Joong
Roh Kyung-Hwan
Ahn Jae-Doo
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Abstract
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N-Hexane which is contained within organic solvents is produced by cracking of crude oil and subsequent fractional distillation, but also from natural gas and coal. Its main use was for oil seed extraction, producing in the rubber industry, in glues (e.g, in the shoe industry), and as solvent in paints, lacquers, and printing ink. Most often n-hexane is mixed with other solvents. We experienced a patient with peripheral polyneuropathy due to chronic exposure of mixed solvents combined with mental deterioration owing to adrenal insufficiency. He had occupational history of dealing with adhesives containing n-hexane over 30 years and suffered from muscle wasting and weakness of all extremities and difficulty of independent ambulation for 2 years. He also had taken herb medications for 3 years intermittently. He had mental deterioration. hyponatremia and low cortisol level in plasma. After rehabilitation program, motor weakness of his lower limbs improved to good degree and mental deterioration was recovered according to coorection of hyponatremia following steroid therapy.
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KEYWORD
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n-Hexane, Organic solvent, Polyneuropathy, Adrenal insufficiency
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